Figure 2

Overview of the p110α/niSH2 heterodimer. (A) Diagram of the p110α/niSH2 heterodimer. The compound YXY-4F bound in the kinase domain is shown as sticks. (B) Surface diagram of the p110α/niSH2 heterodimer, alternate view. The compound YXY-4F bound in the kinase domain is shown as spheres.