Figure 3
The interactions between YXY-4F and p110α. (A) X-ray complex of YXY-4F to p110α (PDB ID: 5XGH). The structure of YXY-4F is shown as a stick representation, and the key binding site residues are shown as sticks. Hydrogen bonds between YXY-4F and the protein are shown as a dashed line Diagram of the p110α/niSH2 heterodimer. (B) Extensive residue–residue interactions on the interface of the YXY-4F-p110α complex structure. The residues belonging to p110α are labeled in ball. A distance between donor and acceptor of less than 3.5 Å indicates a hydrogen bond, and a 4.1 Å distance between two hydrophobic atoms indicates a hydrophobic interaction.
