Table 1 The test compound YXY-4F inhibit proliferation of cancer cella.

From: New Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kα Complexed with a Potent Lead Compound

 

GI50(µM)b

PC-3

Rh30

SKOV3

PI-103

0.449 ± 0.295

0.549 ± 0.312

0.273 ± 0.177

YXY-4F

3.800 ± 0.291

4.570 ± 0.095

2.436 ± 0.312

  1. aCell proliferation was assessed by an SRB assay as described in the Experimental Section. bGI50 values shown are the average ± SD of at least three independent experiments performed in triplicate.
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