Table 3 Three-way pathway comparison of hiPSCs/hESCs, hiPSCs/HFF, and hESCs/HFF.
Pathway | hiPSCs/hESCs (p-val/FDR) | hiPSCs/HFF (p-val/FDR) | hESCs/HFF (p-val/FDR) |
|---|---|---|---|
KEGG: N-glycan biosynthesis | UP 0.006/0.013 | N/A— | N/A— |
REACTOME: post translational protein modification | UP 0.000/0.006 | UP 0.004/0.020 | N/A 0.224/0.601 |
REACTOME: asparagine N-linked glycosylation | UP 0.008/0.037 | UP 0.105/0. 204 | N/A 0.534/0.626 |
KEGG: focal adhesion | UP 0.062/0.111 | DOWN 0.000/0.000 | DOWN 0.000/0.001 |
KEGG: oxidative phosphorylation | DOWN 0.033/0.232 | UP 0.000/0.001 | UP 0.000/0.000 |
REACTOME: TCA cycle and respiratory electron transport | DOWN 0.056/0.187 | UP 0.000/0.004 | UP 0.000/0.001 |
KEGG: Alzheimer’s disease | DOWN 0.066/0.088 | UP 0.159/0.196 | UP 0.084/0.074 |
KEGG: Huntington’s disease | DOWN 0.057/0.113 | UP 0.000/0.001 | UP 0.000/0.000 |
KEGG: Parkinson’s disease | DOWN 0.063/0.150 | UP 0.000/0.001 | N/A— |
REACTOME: respiratory electron transport ATP synthesis by chemiosmotic coupling and heat production by uncoupling proteins | DOWN 0.032/0.223 | UP 0.000/0.003 | N/A — |
REACTOME: mitochondrial protein import | DOWN 0.061/0.144 | N/A — | N/A — |
