Table 3 Label-free differential analysis.
CardioLC versus control (n = 41)(excluding proteins shared with the CardioLC versus MMLC comparison) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Accession | Protein | Gene | Log2FCa | p value | Localization | Notes | ||||
Q969H8 | Myeloid-derived growth factor | MYDGF | −0.717 | 1.08E-04 | ER, Secr. | |||||
O00244 | Copper transport protein ATOX1 | ATOX1 | −0.613 | 5.49E-4 | CY | |||||
Q9BVC6 | Transmembrane protein 109 | TMEM109 | −0.586 | 4.21E-6 | N | |||||
O60493 | Sorting nexin-3 | SNX3 | −0.564 | 9.25E-03 | CY | |||||
P52907 | F-actin-capping protein subunit alpha-1 | CAPZA1 | −0.526 | 6.88E-04 | CS | |||||
Q9NVA2 | Septin-11 | SEPT11 | −0.493 | 6.20E-04 | CS | |||||
P39019 | 40 S ribosomal protein S19 | RPS19 | −0.476 | 7.78E-03 | N, R | |||||
P68104 | Elongation factor 1-alpha 1 | EEF1A1 | −0.443 | 2.47E-03 | CY, N | |||||
P62269 | 40 S ribosomal protein S18 | RPS18 | −0.442 | 5.22E-04 | R | * | ||||
Q6UVK1 | Chondroitin sulfate proteoglycan 4 | CSPG4 | −0.430 | 4.15E-03 | Me | |||||
Q15436 | Protein transport protein Sec. 23 A | SEC. 23 A | −0.415 | 9.55E-04 | ER | |||||
P46782 | 40 S ribosomal protein S5 | RPS5 | −0.414 | 7.23E-04 | R | |||||
Q9NZN4 | EH domain-containing protein 2 | EHD2 | −0.402 | 2.68E-03 | Me | |||||
Q9NZM1 | Myoferlin | MYOF | −0.371 | 3.04E-07 | Me | |||||
P13674 | Prolyl 4-hydroxylase subunit alpha-1 | P4HA1 | −0.355 | 1.77E-03 | ER | |||||
P24539 | ATP synthase subunit b, mitochondrial | ATP5F1 | −0.348 | 8.27E-03 | M | |||||
Q14192 | Four and a half LIM domains protein 2 | FHL2 | −0.345 | 1.05E-03 | N | |||||
P50454 | Serpin H1 | SERPINH1 | −0.340 | 9.17E-04 | ER | |||||
O75083 | WD repeat-containing protein 1 | WDR1 | −0.339 | 7.56E-04 | CS | |||||
P11940 | Polyadenylate-binding protein 1 | PABPC1 | −0.327 | 9.25E-03 | CY | |||||
P18206 | Vinculin | VCL | −0.310 | 1.08E-06 | CS | |||||
O43852 | Calumenin | CALU | −0.306 | 3.14E-03 | ER | |||||
P05388 | 60 S acidic ribosomal protein P0 | RPLP0 | −0.304 | 7.55E-03 | R | |||||
Q15019 | Septin-2 | SEPT2 | −0.298 | 1.86E-04 | CS | |||||
P06733 | Alpha-enolase | ENO1 | −0.269 | 4.93E-03 | CY | |||||
P04792 | Heat shock protein beta-1 | HSPB1 | −0.257 | 8.27E-03 | CY | |||||
P25705 | ATP synthase subunit alpha, mitochondrial | ATP5A1 | −0.255 | 1.79E-03 | M | |||||
Q9P2E9 | Ribosome-binding protein 1 | RRBP1 | −0.255 | 4.96E-04 | ER | |||||
Q96AC1 | Fermitin family homolog 2 | FERMT2 | −0.254 | 5.87E-03 | CS, Me | |||||
P46821 | Microtubule-associated protein 1B | MAP1B | −0.254 | 1.04E-03 | CS | |||||
P36578 | 60 S ribosomal protein L4 | RPL4 | −0.253 | 6.57E-04 | R | |||||
Q16658 | Fascin | FSCN1 | −0.250 | 8.14E-03 | CS | |||||
P78371 | T-complex protein 1 subunit beta | CCT2 | −0.227 | 2.43E-03 | CY | |||||
P14625 | Endoplasmin (Heat shock protein 90 kDa) | HSP90B1 | −0.221 | 3.24E-04 | ER | |||||
P55084 | Trifunctional enzyme subunit beta, mitochondrial | HADHB | −0.220 | 5.23E-03 | M | |||||
P26038 | Moesin | MSN | −0.216 | 1.05E-03 | Me | |||||
P30101 | Protein disulfide-isomerase A3 | PDIA3 | −0.213 | 7.06E-03 | ER | |||||
Q14204 | Cytoplasmic dynein 1 heavy chain 1 | DYNC1H1 | −0.139 | 4.85E-03 | CS | |||||
P35579 | Myosin-9 | MYH9 | 0.182 | 5.71E-04 | CS | |||||
Q00839 | Heterogeneous nuclear ribonucleoprotein U | HNRNPU | 0.398 | 4.45E-06 | N | |||||
P54886 | Delta-1-pyrroline-5-carboxylate synthase | ALDH18A1 | 0.994 | 4.06E-03 | M | |||||
CardioLC versus control and versus MMLC (n = 34) | ||||||||||
CardioLC vs MMLC | CardioLC vs control | |||||||||
Accession | Protein | Gene | Log2FC a | p value | Log2FC a | p value | Local | Notes | ||
Q86VP6 | Cullin-associated NEDD8-dissociated protein 1 | CAND1 | −1.041 | 5.58E-04 | −1.009 | 1.74E-03 | CY | = | ||
P08670 | Vimentin | VIM | −1.029 | 0.00E + 00 | 0.531 | 3.50E-07 | CS | ≠ *** | ||
P61586 | Transforming protein RhoA | RHOA | −0.815 | 7.94E-03 | −0.802 | 4.93E-03 | Me | = | ||
Q9UK76 | Hematological and neurological expressed 1 protein | HN1 | −0.726 | 7.94E-03 | −0.870 | 8.54E-05 | N | = | ||
P21589 | 5’-nucleotidase | NT5E | −0.466 | 2.51E-04 | −0.335 | 5.30E-03 | Me | = | ||
P21964 | Catechol O-methyltransferase | COMT | −0.464 | 2.11E-03 | −0.414 | 3.91E-03 | CY | = | ||
Q14847 | LIM and SH3 domain protein 1 | LASP1 | −0.415 | 4.33E-04 | −0.540 | 1.08E-06 | CS | = | ||
P60891 | Ribose-phosphate pyrophosphokinase 1 | PRPS1 | −0.340 | 3.62E-04 | −0.399 | 6.64E-06 | CY | = | ||
P08123 | Collagen alpha-2(I) chain | COL1A2 | −0.339 | 1.46E-03 | −0.334 | 1.74E-03 | Secr. | = | ||
Q00341 | Vigilin | HDLBP | −0.338 | 2.37E-04 | −0.354 | 2.23E-05 | CY | = | ||
Q14764 | Major vault protein | MVP | −0.326 | 1.06E-03 | −0.279 | 2.64E-03 | CY | = | ||
Q96HC4 | PDZ and LIM domain protein 5 | PDLIM5 | −0.310 | 1.51E-03 | −0.321 | 7.23E-04 | CY | = | ||
P98095 | Fibulin-2 | FBLN2 | −0.303 | 9.72E-04 | −0.261 | 5.81E-03 | Secr. | = | ||
P08758 | Annexin A5 | ANXA5 | −0.283 | 8.73E-03 | −0.276 | 5.81E-03 | CY, Me | = | ||
O60701 | UDP-glucose 6-dehydrogenase | UGDH | −0.272 | 2.17E-03 | −0.261 | 2.89E-03 | CY | = | ||
P02751 | Fibronectin | FN1 | −0.271 | 5.58E-04 | −0.325 | 1.25E-04 | Secr. | = | ||
Q00610 | Clathrin heavy chain 1 | CLTC | −0.269 | 1.43E-05 | −0.261 | 3.23E-06 | Me | = | ||
P27816 | Microtubule-associated protein 4 | MAP4 | −0.265 | 9.36E-04 | −0.223 | 3.87E-03 | CS | = | ||
P08133 | Annexin A6 | ANXA6 | −0.263 | 8.15E-03 | −0.316 | 4.07E-04 | CY | = | ||
Q13642 | Four and a half LIM domains protein 1 | FHL1 | −0.261 | 4.83E-03 | −0.391 | 7.55E-07 | CY | = | ||
P15924 | Desmoplakin | DSP | −0.258 | 7.56E-05 | −0.316 | 7.72E-08 | CS | = | ||
P13639 | Elongation factor 2 | EEF2 | −0.246 | 3.00E-03 | −0.292 | 7.19E-05 | CY, N | = | ||
P07355 | Annexin A2 | ANXA2 | −0.239 | 2.87E-03 | −0.252 | 6.31E-04 | Me | = | ||
Q05682 | Caldesmon | CALD1 | −0.230 | 1.43E-05 | −0.235 | 2.75E-06 | CS | = | ||
P21333 | Filamin-A | FLNA | −0.226 | 3.16E-08 | −0.265 | 8.11E-12 | CS | = | ||
Q14315 | Filamin-C | FLNC | −0.216 | 2.19E-04 | −0.246 | 3.20E-06 | CS | = | ||
O43707 | Alpha-actinin-4 | ACTN4 | −0.201 | 2.37E-04 | −0.304 | 2.63E-10 | CS | = | ||
Q15149 | Plectin | PLEC | −0.199 | 3.54E-05 | −0.295 | 1.71E-12 | CS | = | ||
P46940 | Ras GTPase-activating-like protein IQGAP1 | IQGAP1 | −0.194 | 2.15E-03 | −0.256 | 3.42E-06 | CS, Me | = | ||
P22314 | Ubiquitin-like modifier-activating enzyme 1 | UBA1 | −0.191 | 1.13E-03 | −0.284 | 3.13E-08 | CY, N | = | ||
O75369 | Filamin-B | FLNB | −0.184 | 1.43E-05 | −0.183 | 3.20E-06 | CS | = | ||
Q9Y490 | Talin-1 | TLN1 | −0.156 | 1.60E-04 | −0.245 | 1.73E-11 | CS | = | ||
Q09666 | Neuroblast differentiation-associated protein AHNAK | AHNAK | −0.143 | 1.07E-04 | −0.196 | 2.74E-09 | N | = | ||
Q16527 | Cysteine and glycine-rich protein 2 | CSRP2 | 0.930 | 1.60E-04 | 1.031 | 5.73E-05 | N | = | ||
CardioLC versus MMLC (n = 7) (excluding proteins shared with the CardioLC versus Control comparison) | ||||||||||
Accession | Protein | Gene | Log2FC a | p value | Localization | Notes | ||||
P27144 | GTP:AMP phosphotransferase AK4, mitochondrial | AK4 | −1.156 | 4.33E-04 | M | |||||
P51911 | Calponin-1 | CNN1 | −0.365 | 6.45E-03 | CS | |||||
P02545 | Prelamin-A/C | LMNA | −0.348 | 5.31E-05 | N | |||||
P13797 | Plastin-3 | PLS3 | −0.318 | 7.94E-03 | CY | |||||
Q13813 | Spectrin alpha chain, non-erythrocytic 1 | SPTAN1 | −0.298 | 3.62E-04 | CS | ** | ||||
P56537 | Eukaryotic translation initiation factor 6 | EIF6 | 0.501 | 1.13E-03 | CY | |||||
O75390 | Citrate synthase, mitochondrial | CS | 0.944 | 9.18E-03 | M | |||||
MMLC versus control (n = 4) | ||||||||||
Accession | Protein | Gene | Log2FC a | p value | Localization | Notes | ||||
P62269 | 40 S ribosomal protein S18 | RPS18 | −0.476 | 4.30E-04 | R | * | ||||
Q01082 | Spectrin beta chain, non-erythrocytic 1 | SPTBN1 | 0.240 | 3.94E-03 | CS | |||||
Q13813 | Spectrin alpha chain, non-erythrocytic 1 | SPTAN1 | 0.266 | 4.34E-03 | CS | ** | ||||
P08670 | Vimentin | VIM | 1.561 | 0.00E + 00 | CS | *** | ||||
