Figure 1 | Scientific Reports

Figure 1

From: Catabolic Effects of Human PTH (1–34) on Bone: Requirement of Monocyte Chemoattractant Protein-1 in Murine Model of Hyperparathyroidism

Figure 1

MCP-1 is required for cPTH-induced cortical bone loss. (A) Effect of continuous hPTH infusion on serum hPTH levels. Serum hPTH significantly increased in WT and MCP-1−/− mice. (B) Serum MCP-1 levels are significantly increased in WT mice after cPTH infusion. (C) MCP-1 gene expression after cPTH infusion. (D) Total serum calcium (mmol/L). (E) Change in body weight (BW) in gram (gm). (F) Cortical bone mineral density (vBMD cortical) in (gm/cm3). MCP-1−/− mice did not show loss of cortical BMD after cPTH infusion as seen in WT mice. (G) cPTH infusion increased cortical porosity in WT mice while not affecting this parameter in MCP-1−/− mice. (H) Representative µCT images of the cortical region of the femurs. (I–N) µCT analysis of cortical bone in the femurs of mice showing BV/TV (%), T.Ar (mm2), B.Pm (mm), B.Ar (mm2), Cs.Th (mm) and MMI polar. All values are expressed as mean ± SEM (n = 10–14 mice/group) *p < 0.05, **p < 0.01 and ***p < 0.001 compared to vehicle-infused WT mice.

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