Figure 1

Quantification of fine motor function, assessed via horizontal ladder crossing time. Animals were grouped into un-implanted control or implanted experimental group (A). Significant differences were seen between control and implanted animals for post-surgical weeks 3–16 (*p < 0.05, **p < 0.01) and longitudinally across the course of the entire study (#p < 0.05). Implanted animals were further separated into ‘good’ and ‘poor’ performing to highlight variability within the experimental group (B). During the ladder test, the occurrence of right paw slips was quantified (C). A significant difference was seen in the number of right paw slips per week between control and implanted animals (*p < 0.05, **p < 0.01). Example paw slip (D). \( \% \,{\rm{change}}\,{\rm{in}}\,{\rm{performance}}=\frac{(baseline\,time\,-\,weekly\,test\,time)}{baseline\,time}\ast (100)\). All error reported as SEM.