Figure 2
From: α subunits in GABAA receptors are dispensable for GABA and diazepam action
Concentration response curve for diazepam at β2γ2 GABAA receptors. Receptors were expressed in Xenopus oocytes and exposed to either GABA alone or GABA in the presence of subsequently higher concentrations of diazepam and the elicited current amplitude was determined. At each concentration of diazepam current potentiation was calculated. Individual curves for potentation were first normalized to the fitted maximal current amplitude and subsequently averaged. Data are expressed as mean ± S.E.M., n = 3 from two batches of oocytes. (a) Original current traces. (b) Averaged concentration-response curve for β2γ2 GABAA receptors. The dotted line shows for comparison corresponding data on α1β2γ2 GABAA receptors.
