Table 4 The combined information for the 5 potential target genes/proteins that germacrone, curdione on breast cancer.
Genes ID | Other Name | Common name | Scores in BATMAN-TCM | KEGG Pathway | Entrez ID | GO Functions |
|---|---|---|---|---|---|---|
ESR1 | ER; ESR; ESRA; ESTRR; Era; NR3A1 | estrogen receptor 1 | 80.882 | Estrogen signaling pathway;Prolactin Signaling Pathway | 2099 | Involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. |
ESR2 | ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 | 22.373 | Estrogen Signaling Pathway;Prolactin Signaling Pathway | 2100 | The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. |
SRC | ASV; SRC1; THC6; c-SRC; p60-Src | tyrosine-protein kinase Src | 22.373 | Estrogen Signaling Pathway;Prolactin Signaling Pathway;Oxytocin Signaling Pathway; | 6714 | May play a role in the regulation of embryonic development and cell growth. |
TP53 | BCC7; LFS1; P53; TRP53 | tumor protein p53 | 22.373 | P53 Signaling Pathway | 7157 | Mutations in this gene are associated with a variety of human cancers |
VDR | NR1I1; PPP1R163 | vitamin D (1,25- dihydroxyvitamin D3) receptor | 22.373 | Endocrine And Other Factor-Regulated Calcium Reabsorption;Mineral Absorption | 7421 | Principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. |
