Figure 3

MAFs measured in multiple peripheral tissue samples of the mosaic parents. The color of each cell represents a different MAF. Each column represents a family affected by DS, sorted by the MAFs in the mosaic parents’ blood. Each row represents a tissue or sample type. Hierarchical clustering of square-root transformed MAFs from different sample types shows that samples from the same mosaic parent cluster together, and parental blood and saliva have more similar MAFs than oral epithelia. Hair follicle samples from mosaic parents cluster closer to the paternal sperm samples than to the urine samples. Blood samples from controls and non-mosaic parents all have MAFs of approximately 0% and are clustered together. The heterozygous probands have MAFs of approximately 50%. Multiple tissue and control MAFs analyzed by mDDPCR are shown in Supplementary Fig. S8.