Figure 2
From: A Feline HFpEF Model with Pulmonary Hypertension and Compromised Pulmonary Function
Hemodynamics before and after dobutamine stress testing. ( a) LVPmax was higher in banded cats. (b) CO was similar between groups. (c) Dp/dtmax was attenuated in banded animals after dobutamine. Banded animals showed elevated LVEDP (d) and mPAP (e). τ was prolonged (f), t-dia/ τ (g) and dP/dtmin (h) were reduced after aortic banding, indicative of impaired relaxation. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 between groups. †p < 0.05, ††p < 0.01, †††p < 0.001, ††††p < 0.0001 vs BL. BL = baseline, CO = cardiac output, dP/dtmax = maximum rate of pressure rise, dP/dtmin = maximum rate of pressure decay, LVEDP = left ventricular end-diastolic pressure, LVPmax = maximum left ventricular pressure, mPAP = mean arterial pulmonary pressure, τ = isovolumic relaxation constant, t-dia = diastolic time interval.
