Figure 6
From: A Feline HFpEF Model with Pulmonary Hypertension and Compromised Pulmonary Function
Morphological lung changes. ( a,b) Increased wet/dry lung weight ratio and protein content in banded vs sham cats is suggestive of endothelial leaking. (c) Alveolar-capillary wall thickness was increased in banded vs sham cats. Alveolar area (d) and expansion index (e), the ratio of volume of gas exchange to parenchymal space, were decreased in banded vs sham cats. (f) Ratio of cuff/vessel area of extra-alveolar vessels was increased in banded vs sham cats. (g,h) Bright-field micrographs of H&E-stained lung sections. * = bronchioles, † = extra-alveolar vessel, arrow = fluid cuff around extra-alveolar vessels. Scale bars = 250 µm. *p < 0.05, **p < 0.01, ***p < 0.001 between groups.
