Table 1 Parameters and initial conditions for the mathematical model.
Name | Value | Units | Reference |
|---|---|---|---|
Growth rate of Tumor (g) | 0.2 | μm/min | |
Tumor death rate due to TIL (k) | 0.0015 | μm/min/cell | |
Kinetic speed of APCOFF | 12 | μm/min | |
Chemotactic speed of APCOFF | 4 | μm/min | |
Kinetic speed of APCM | 20 | μm/min | |
Chemotactic speed of APCM | 10 | μm/min | |
Kinetic speed of T cells | 10 | μm/min | |
Chemotactic speed of T cells | 100 | μm/min | |
Rate of adding new APCOFF to simulation | 0.84 | per min | model specific |
Rate of adding new inactive T cells to simulation | 0.1 | per min | model specific |
Lifespan of a TIL before expiration | 1 | day | model specific |
Max distance between two cells for activation to occur | 15 | μm | model specific |
Initial Conditions: | |||
Initial radius of the Tumor | 200 | μm | model specific |
Radius of the ELN patch | 750 | μm | model specific |
Distance from tumor to ELNs patch | 2000 | μm | model specific |
Initial T-cell number | 30 | cells | model specific |
Initial APCOFF number | 10 | cells | model specific |
