Table 2 Baseline and post treatment RASs in patients failing DAAs.
From: Baseline and Breakthrough Resistance Mutations in HCV Patients Failing DAAs
#Patient | Genotype | Ongoing therapy (weeks) | Mutations | Drugs with reduced sensitivity | Outcome | Previous Therapy | ||
|---|---|---|---|---|---|---|---|---|
NS3 | NS5A | NS5B | ||||||
1 BLPost | 1A | Sim+Sof +RBV (12) | 36M,54S,155K,174S 36M,54S,155K,174S | 31Mnone | nonenone | Asu,Par,Sim,Boc,Tel, Graz,Vel | relapser | Peg/RBV/Telaprevir |
2 BLPost | 1A | Sim+Sof+RBV (24) | 80K,174S 80K,174S | nonenone | nonenone | Sim,Tel | Non responder | Peg/RBV |
3 BLPost | 1A | Omb+Par+Das+RTV+RBV(12) | 80K 80K,D168V | 93N93N | none444D,556G | Asu,Par,Sim,Graz Dacl,Led,Vel,Omb,Das | relapser | Peg/RBV |
4 BLPost | 1A | Omb+Par+Das+RTV+RBV(12) | 80K 80K,168Y | none30R | none414T,444D | Par,Dacl,Elb,Led,Omb,Das, | relapser | Peg/RBV |
5 BLPost | 1A | Sof+Dacl+RBV(12) | NAnone | NA30H | NAnone | Dacl,Elb,Led | Non responder | none |
6 BLPost | 1A | Omb+Par+Das+RTV+RBV(12) | NA174S | NA28V | NAnone | Omb | relapser | Peg/RBV |
7 BLPost | 1B | Sof+Led(24) | nonenone | none31I,93H | 159F,316N 159F,282T,316N,451N | Dacl,Elb,Led,Omb,Vel,Sof,Das | relapser | Peg/RBV |
8 BLPost | 1B | Sim+Sof(12) | nonenone | nonenone | 159F,316N,451S 159F,316N,451S | Das,Sof | relapser | Peg/RBV |
9 BLPost | 1B | Sim+Sof(12) | 36V,80R,170V36V,80R,168E,170V | 30R30R | 159F,316N,451S 159F,316N,451S,556G | Sim,Par,Das,Sof | relapser | Peg/RBV |
10 BLPost | 1B | Sim+Sof(12) | none168V | 30R,93H30R,31M,93H | 159F,316N,451S 159F,282T,316N,451S,556G | Sim,Par,Led,Dacl,Elb,Vel,Das, Sof | Non responder | Peg/RBV |
11 BLPost | 1B | Sim+Sof(12) | nonenone | 30R30R | nonenone | None | relapser | Peg/RBV |
12 BLPost | 1B | Sof+Dacl(12) | NAnone | NA93H | NAnone | Dacl,Elb,Led,Omb,Vel | relapser | none |
13 BLPost | 1B | Sof+Dacl(24) | nonenone | none31I,93H | 159F,316N,451Y 159F,316N,451Y | Dacl,Elb,Led,Omb,Vel,Sof,Das | relapser | Peg/RBV |
14 BLPost | 1B | Led+Sof+RBV(12) | NA | NA31M,58S,93H | NAnone | Dacl,Elb,Led,Omb,Vel | relapser | Peg/RBV |
15 BLPost | 1B | Led+Sof+RBV(12) | none170I | none31M,93H | none159F,316N,451N,556G | GrazDacl,Elb,Led,OmbVel,Sof,Das, | relapser | Peg/RBV |
16 BLPost | 1b/2k | Sof+RBV(24) | NAnone | NAnone | NAnone | None | relapser | Peg/RBV |
17 BLPost | 2C | Sof+RBV(24) | 36L,122R,174S36L,122R,174S | 30R30R | nonenone | None | relapser | Peg/RBV/Telaprevir |
18 BLPost | 2C | Sof+RBV(24) | 36L,122R,174S36L,122R,174S | 30K30R | 556G556G | None | relapser | Peg/RBV |
19 BLPost | 2C | Sof+RBV(24) | NAnone | NAnone | NA553V, 556G | None | Non responder | Peg/RBV |
20 BLPost | 2C | Sof+RBV(24) | nonenone | 30K30K | nonenone | None | relapser | Peg/RBV |
21 BLPost | 3A | Omb+Par+Das+RTV(12) | 36L,168Q36L,80K,168Q | none93H | 553V,556G553V,556G | Dacl,Led,Omb,Elb,Vel | Non responder | Sim+Sof |
22 BLPost | 3A | Sof+RBV(24) | 36L,168Q36L,168Q | 93H93H | 553V,556G553V,556G | Dacl,Led,Omb,Elb,Vel | relapser | Peg/RBV/Boceprevir |
23 BLPost | 3A | Sof+RBV(24) | NA36L,168Q | NAnone | NAnone | None | relapser | none |
24 BLPost | 3A | Sof+RBV(24) | 36L,168Q36L,168Q | nonenone | 553V,556G553V,556G | None | relapser | Peg/RBV |
25 BLPost | 3A | Sof+RBV(24) | NA36L,168Q | NAnone | NAnone | None | relapser | none |
26 BLPost | 3A | Sof+RBV(24) | NA36L,168Q | NAnone | NA553V,556G | None | relapser | Peg/RBV |
27 BLPost | 3A | Sof+Dacl+RBV(24) | NA36L,168Q | NA93H | NA553V, 556G | Dacl,Led,Omb,Elb,Vel | relapser | Peg/RBV |
28 BLPost | 1A3A | Omb+Par+Das+RTV(12) | 80Knone | none93H | 556Gnone | Dacl,Led, Omb,Elb,Vel | relapser | Peg/RBV |
29 BLPost | 4D | Sof+RBV(24) | NA36L, 174S | NA30R,31M | NA414I,553V,556G | None | relapser | Peg/RBV |
30 BLPost | 4D | Sim+Sof(12) | 36L,174S36L,80K,174S | 30R,31M30R,31M | 414I,553V,556G414I,553V,556G | None | relapser | Peg/RBV |
31 BLPost | 4D | Sof+pegIFN+RBV(24) | NA36L,174S | NA30R,31M | NA414I,553V,556G | None | relapser | none |
