Figure 1 | Scientific Reports

Figure 1

From: Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patients

Figure 1

Comparison of the Raman microscopy results with conventionally stained brain sections. White light image from Raman microscope with boxed area indicating the Raman scan region of interest (ROI). Unstained 50 µm thick sections were used for Raman imaging (left panel) and 5 to 8 µm thick sections from an adjacent tissue block were used for conventional histology (right panel). Corresponding Raman intensity image for β-sheets distribution is given next to it. Conventional brain histopathology from the same samples show a neuritic plaque (upper row) and neurofibrillary tangle (lower row), with silver impregnation (Silver Stain) and immunohistochemistry for amyloid-β (Aβ) and hyperphosphorylated tau protein (Tau). Note the lack of Aβ immunostaining of neurofibrillary tangles. Image size is given below and tissue ID numbers are given on the right.

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