Figure 1
From: Histamine N-methyltransferase regulates aggression and the sleep-wake cycle
Hnmt deficiency increases brain histamine levels. (A) Histamine content in cortex, diencephalon, brainstem, and cerebellum homogenates (n = 5). 1-mHA, 1-methylhistamine; HA, histamine; n.d., not detected. (B) Histamine content in whole brain homogenates at various ages (n = 5–9). White bars, wild type (WT); black bars, knockout (KO). Student’s t-test, *p < 0.05. (C) Extracellular histamine concentrations in the hypothalamic area of WT (white circles) and KO mice (black square) for 24 h. Light period (white horizontal bar): ZT0-12, Dark period (black horizontal bar): ZT12-24 (n = 8).
