Figure 7

Control of mannitol production by transcriptionally regulated enzymes. Effect of flux through PGI (glucose-6-phosphate isomerase), RPE (ribulose 5-phosphate 3-epimerase) and ACALD (acetaldehyde dehydrogenase) on mannitol production. The flux through each of these reactions was varied from a value optimal for growth to a minimum feasible value determined by flux variability analysis and the corresponding mannitol production fluxes were recorded. WT flux: Wild type flux or flux optimal for growth.