Figure 6
β-Eudesmol derived GVNA elevation involves the histamine H3 receptor. (A,B) Changes in β-eudesmol derived GVNA in rats previously administered thioperamide (n = 5). (C) Histamine concentration in the tuberomammillary nucleus in β-eudesmol administered rats (n = 5). The histamine concentration at 100% was 17.5 fmol/20 μl (CTL) and 19.1 fmol/20 μl (β-EUD). (D) In vitro histamine H3 receptor activity measurements. (E,F) The effects of subdiaphragmatic vagotomy on β-eudesmol derived GVNA elevation (n = 5). Statistical differences were analyzed by the Mann-Whitney U test or the Kruskal Wallis test followed by Steel-Dwass. *p < 0.05; **p < 0.01. CTL, control; β-EUD, β -eudesmol; n. s., not significant; α-MH, α-methylhistamine.
