Figure 3
TAK-242 administration results in reduced Ly6Chi cells in peripheral blood, bone marrow and spleen. Flow cytometry analysis showed that TAK-242 treatment could reduce the percentage of ly-6Chi monocytes among CD11b+ cells in peripheral blood (A) and bone marrow (B), but not the spleen (C) after allogeneic aorta transplantation, as compared with vehicle-treated control. (D) Spleens were obtained from the vehicle-, TAK-242-treated allogeneic or isogeneic transplanted mice. TAK-242 treatment resulted in reduced weight of spleen. (n = 4 mice for per group, *P < 0.05; **P < 0.01).
