Table 1 List of candidate targets of miR-34a and miR-449a predicted by miRDB.

100

Arhgap26

Rho GTPase activating protein 26

100

Erc1

ELKS/RAB6-interacting/CAST family member 1

100

Erc1

ELKS/RAB6-interacting/CAST family member 1

100

Arhgap26

Rho GTPase activating protein 26

100

Vamp2

vesicle-associated membrane protein 2

100

Vamp2

vesicle-associated membrane protein 2

100

Syt1

synaptotagmin I

100

Syt1

synaptotagmin I

99

E2f5

E2F transcription factor 5

99

E2f5

E2F transcription factor 5

99

Tbc1d2b

TBC1 domain family, member 2B

99

Fam76a

family with sequence similarity 76, member A

99

Fam76a

family with sequence similarity 76, member A

99

Tbc1d2b

TBC1 domain family, member 2B

99

Ppp2r5a

protein phosphatase 2, regulatory subunit B′, alpha

99

Mpp2

membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

99

Mpp2

membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

99

Ppp2r5a

protein phosphatase 2, regulatory subunit B′, alpha

99

Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11

99

Notch1

notch 1

99

Notch1

notch 1

98

Ttc19

tetratricopeptide repeat domain 19

98

Ttc19

tetratricopeptide repeat domain 19

98

Osgin2

oxidative stress induced growth inhibitor family member 2

98

Zfhx4

zinc finger homeodomain 4

98

Zfhx4

zinc finger homeodomain 4

98

Akap6

A kinase (PRKA) anchor protein 6

98

Slc6a1

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

98

Abr

active BCR-related gene

98

Zfp644

zinc finger protein 644

98

Camta1

calmodulin binding transcription activator 1

98

Camta1

calmodulin binding transcription activator 1

98

Slc6a1

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

98

Abr

active BCR-related gene

98

Osgin2

oxidative stress induced growth inhibitor family member 2

98

Slc44a2

solute carrier family 44, member 2

98

Zfp644

zinc finger protein 644

98

Akap6

A kinase (PRKA) anchor protein 6

97

Ubl4

ubiquitin-like 4

97

Mmp25

matrix metallopeptidase 25

97

Hspb6

heat shock protein, alpha-crystallin-related, B6

97

Il6ra

interleukin 6 receptor, alpha

97

Pitpnc1

phosphatidylinositol transfer protein, cytoplasmic 1

97

Mycn

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

97

Il6ra

interleukin 6 receptor, alpha

97

Calcr

calcitonin receptor

97

Mmp25

matrix metallopeptidase 25

97

Hspb6

heat shock protein, alpha-crystallin-related, B6

97

Pnoc

prepronociceptin

97

Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11

97

Mycn

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

97

Pitpnc1

phosphatidylinositol transfer protein, cytoplasmic 1

97

Tmem79

transmembrane protein 79

97

Cbfa2t3

core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)

97

Zfp775

zinc finger protein 775

97

4930544G11Rik

RIKEN cDNA 4930544G11 gene

97

Cbfa2t3

core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)

97

Ubl4

ubiquitin-like 4

97

Soga1

suppressor of glucose, autophagy associated 1

97

Pnoc

prepronociceptin

97

Fbxo30

F-box protein 30

97

Tmem79

transmembrane protein 79

97

Nfam1

Nfat activating molecule with ITAM motif 1

97

Arhgap1

Rho GTPase activating protein 1

97

Calcr

calcitonin receptor

97

Fbxo30

F-box protein 30

97

Arhgap1

Rho GTPase activating protein 1

96

Cntn2

contactin 2

96

Ddx17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

96

Ddx17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

96

Ctnnd2

catenin (cadherin associated protein), delta 2

96

Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

96

Hexa

hexosaminidase A

96

Ctnnd2

catenin (cadherin associated protein), delta 2

96

Pacs1

phosphofurin acidic cluster sorting protein 1

96

Pacs1

phosphofurin acidic cluster sorting protein 1

96

Cuedc1

CUE domain containing 1

96

Hexa

hexosaminidase A

96

Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

95

Pogz

pogo transposable element with ZNF domain

96

Cntn2

contactin 2

95

Ppp2r3a

protein phosphatase 2, regulatory subunit B″, alpha

95

Pogz

pogo transposable element with ZNF domain

95

Sfmbt2

Scm-like with four mbt domains 2

95

Snx15

sorting nexin 15

95

Dgkz

diacylglycerol kinase zeta

95

Tbl1xr1

transducin (beta)-like 1X-linked receptor 1

95

Tbl1xr1

transducin (beta)-like 1X-linked receptor 1

95

Dgkz

diacylglycerol kinase zeta

95

Lef1

lymphoid enhancer binding factor 1

95

Lef1

lymphoid enhancer binding factor 1

95

Satb2

special AT-rich sequence binding protein 2

95

Sfmbt2

Scm-like with four mbt domains 2

94

Astn1

astrotactin 1

94

Ahcyl2

S-adenosylhomocysteine hydrolase-like 2

94

Eml5

echinoderm microtubule associated protein like 5

94

Slc44a2

solute carrier family 44, member 2

94

Ranbp10

RAN binding protein 10

94

Eml5

echinoderm microtubule associated protein like 5

94

Met

met proto-oncogene

94

Ranbp10

RAN binding protein 10

94

Strn3

striatin, calmodulin binding protein 3

94

Astn1

astrotactin 1

94

Zmym4

zinc finger, MYM-type 4

94

Strn3

striatin, calmodulin binding protein 3

94

Hnf4a

hepatic nuclear factor 4, alpha

94

Met

met proto-oncogene

94

Rfx3

regulatory factor X, 3 (influences HLA class II expression)

94

Hnf4a

hepatic nuclear factor 4, alpha

94

Ahcyl2

S-adenosylhomocysteine hydrolase-like 2

94

Rfx3

regulatory factor X, 3 (influences HLA class II expression)

93

Pkp4

plakophilin 4

94

Zmym4

zinc finger, MYM-type 4

93

Ubp1

upstream binding protein 1

93

Slc4a7

solute carrier family 4, sodium bicarbonate cotransporter, member 7

93

Tmem255a

transmembrane protein 255 A

93

Tmem255a

transmembrane protein 255 A

93

Etl4

enhancer trap locus 4

93

Pkp4

plakophilin 4

93

Slc4a7

solute carrier family 4, sodium bicarbonate cotransporter, member 7

93

Tmem55a

transmembrane protein 55 A

92

Iqgap3

IQ motif containing GTPase activating protein 3

93

Ubp1

upstream binding protein 1

92

Nav3

neuron navigator 3

93

Etl4

enhancer trap locus 4

92

Trim67

tripartite motif-containing 67

92

Scml2

sex comb on midleg-like 2 (Drosophila)

92

Scml2

sex comb on midleg-like 2 (Drosophila)

92

Taf5

TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor

92

Papss2

3′-phosphoadenosine 5′-phosphosulfate synthase 2

92

Iqgap3

IQ motif containing GTPase activating protein 3

92

Taf5

TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor

92

Uhrf2

ubiquitin-like, containing PHD and RING finger domains 2

92

Plcb1

phospholipase C, beta 1

92

Rtn4rl1

reticulon 4 receptor-like 1

92

Daam1

dishevelled associated activator of morphogenesis 1

92

Daam1

dishevelled associated activator of morphogenesis 1

92

Nat8l

N-acetyltransferase 8-like

92

Papss2

3′-phosphoadenosine 5′-phosphosulfate synthase 2

92

Rtn4rl1

reticulon 4 receptor-like 1

92

Plcb1

phospholipase C, beta 1

92

Uhrf2

ubiquitin-like, containing PHD and RING finger domains 2

92

Trim67

tripartite motif-containing 67

92

Vdr

vitamin D receptor

92

Vdr

vitamin D receptor

92

Slc35g2

solute carrier family 35, member G2

92

4930544G11Rik

RIKEN cDNA 4930544G11 gene

91

Coro1c

coronin, actin binding protein 1 C

92

Nav3

neuron navigator 3

91

Stag3

stromal antigen 3

92

Nat8l

N-acetyltransferase 8-like

91

H6pd

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

91

Lzts3

leucine zipper, putative tumor suppressor family member 3

91

Crkl

v-crk sarcoma virus CT10 oncogene homolog (avian)-like

91

Stag3

stromal antigen 3

91

Soga1

suppressor of glucose, autophagy associated 1

91

Pea15a

phosphoprotein enriched in astrocytes 15 A

91

Vat1

vesicle amine transport protein 1 homolog (T californica)

91

Padi2

peptidyl arginine deiminase, type II

91

Padi2

peptidyl arginine deiminase, type II

91

H6pd

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

91

Pea15a

phosphoprotein enriched in astrocytes 15 A

91

Coro1c

coronin, actin binding protein 1 C

91

Rps6ka4

ribosomal protein S6 kinase, polypeptide 4

91

Rps6ka4

ribosomal protein S6 kinase, polypeptide 4

91

Frk

fyn-related kinase

91

Frk

fyn-related kinase

90

Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

91

Vat1

vesicle amine transport protein 1 homolog (T californica)

90

Ing5

inhibitor of growth family, member 5

91

Crkl

v-crk sarcoma virus CT10 oncogene homolog (avian)-like

90

Tmem25

transmembrane protein 25

90

Itsn1

intersectin 1 (SH3 domain protein 1 A)

90

Itsn1

intersectin 1 (SH3 domain protein 1 A)

90

Tmem25

transmembrane protein 25

90

Car7

carbonic anhydrase 7

90

Ing5

inhibitor of growth family, member 5

90

Ccne2

cyclin E2

90

Gpr158

G protein-coupled receptor 158

90

Gpr158

G protein-coupled receptor 158

90

Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

90

Map1a

microtubule-associated protein 1 A

90

Pdgfrb

platelet derived growth factor receptor, beta polypeptide

89

Cuedc1

CUE domain containing 1

90

Car7

carbonic anhydrase 7

89

Zfp120

zinc finger protein 120

90

Ccne2

cyclin E2

89

Tom1

target of myb1 homolog (chicken)

89

Srpr

signal recognition particle receptor (‘docking protein’)

89

Patz1

POZ (BTB) and AT hook containing zinc finger 1

89

Zfp120

zinc finger protein 120

89

Srpr

signal recognition particle receptor (‘docking protein’)

89

Satb2

special AT-rich sequence binding protein 2

89

Vwa5b2

von Willebrand factor A domain containing 5B2

89

Tom1

target of myb1 homolog (chicken)

89

S1pr3

sphingosine-1-phosphate receptor 3

89

Casp2

caspase 2

89

Nfam1

Nfat activating molecule with ITAM motif 1

89

S1pr3

sphingosine-1-phosphate receptor 3

89

Casp2

caspase 2

89

Vwa5b2

von Willebrand factor A domain containing 5B2

88

Scn2b

sodium channel, voltage-gated, type II, beta

89

Patz1

POZ (BTB) and AT hook containing zinc finger 1

88

Sar1a

88

Sar1a

SAR1 gene homolog A (S. cerevisiae)

88

Nup210

nucleoporin 210

88

Rragc

Ras-related GTP binding C

88

Pdgfra

platelet derived growth factor receptor, alpha polypeptide

88

Scn2b

sodium channel, voltage-gated, type II, beta

88

Nrip3

nuclear receptor interacting protein 3

88

Nup210

nucleoporin 210

88

Ddn

dendrin

88

Pdgfra

platelet derived growth factor receptor, alpha polypeptide

88

Rragc

Ras-related GTP binding C

88

Ddn

dendrin

87

Scamp4

secretory carrier membrane protein 4

88

Nrip3

nuclear receptor interacting protein 3

87

Tgif2

TGFB-induced factor homeobox 2

87

Fam167a

family with sequence similarity 167, member A

87

Ltbp2

latent transforming growth factor beta binding protein 2

87

Fam46a

family with sequence similarity 46, member A

87

Fam46a

family with sequence similarity 46, member A

87

Wasf1

WAS protein family, member 1

87

Wasf1

WAS protein family, member 1

87

Ltbp2

latent transforming growth factor beta binding protein 2

87

Fam167a

family with sequence similarity 167, member A

87

Tgif2

TGFB-induced factor homeobox 2

87

Stk10

serine/threonine kinase 10

87

Scamp4

secretory carrier membrane protein 4

86

Gmfb

glia maturation factor, beta

87

Stk10

serine/threonine kinase 10

86

Metap1

methionyl aminopeptidase 1

86

Metap1

methionyl aminopeptidase 1

86

Fam131b

family with sequence similarity 131, member B

86

Dpysl4

dihydropyrimidinase-like 4

86

Celf3

CUGBP, Elav-like family member 3

86

Gmfb

glia maturation factor, beta

86

Lman1

lectin, mannose-binding, 1

86

Lman1

lectin, mannose-binding, 1

86

Angpt1

angiopoietin 1

86

Ppp2r3a

protein phosphatase 2, regulatory subunit B″, alpha

86

Isg20

interferon-stimulated protein

86

Celf3

CUGBP, Elav-like family member 3

85

Usf1

upstream transcription factor 1

86

Fam131b

family with sequence similarity 131, member B

85

Gpr165

G protein-coupled receptor 165

85

Dip2c

DIP2 disco-interacting protein 2 homolog C (Drosophila)

85

Gmnc

geminin coiled-coil domain containing

85

Gpr165

G protein-coupled receptor 165

85

Synj1

synaptojanin 1

85

Sec61a1

Sec61 alpha 1 subunit (S. cerevisiae)

85

Dip2c

DIP2 disco-interacting protein 2 homolog C (Drosophila)

85

Gmnc

geminin coiled-coil domain containing

85

Rnf4

ring finger protein 4

85

Synj1

synaptojanin 1

85

Sec61a1

Sec61 alpha 1 subunit (S. cerevisiae)

85

Usf1

upstream transcription factor 1

85

Rnf4

ring finger protein 4