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Figure 1

From: AFM-based detection of glycocalyx degradation and endothelial stiffening in the db/db mouse model of diabetes

Figure 1

Examples of indentation data recorded in the experiment and method of analysis. (A) An indentation curve recorded for an endothelial cell body (referred to as a type 1a curve). (B) An indentation curve recorded for an endothelial cell body directly over the cell nucleus (type 1b curve). (C) Indentation curve recorded for an endothelial cell covered with the glycocalyx brush (type 2 curve). Top row: Schemes of indentation geometry. Middle row: Results of the Hertz model fit in the fragment of the contact point (CP) and in the fragment near the maximal load (ML). The dashed lines show the fit to the ML fragment, and solid lines show the fit to the CP fragment. Bottom row: Ad hoc brush model fit to the CP fragment of the curves.

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