Table 2 Distribution frequency of FSCN1 genotypes in controls and patients with breast cancer.
From: FSCN1 gene polymorphisms: biomarkers for the development and progression of breast cancer
Variable | Controls N = 222 (%) | Patients N = 316 (%) | OR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|
rs56156320 | ||||
AA | 179 (80.6) | 231 (73.1) | 1.00 (reference) | 1.00 (reference) |
AC | 14 (6.3) | 34 (10.8) | 1.882 (0.980–3.613) | 2.060 (1.020–4.157)* |
CC | 29 (13.1) | 51 (16.1) | 1.363 (0.830–2.237) | 1.566 (0.914–2.682) |
AC + CC | 43 (19.4) | 85 (26.9) | 1.532 (1.011–2.321)* | 1.736 (1.105–2.727)* |
rs8772 | ||||
CC | 180 (81.1) | 251 (79.4) | 1.00 (reference) | 1.00 (reference) |
CT | 37 (16.7) | 62 (19.6) | 1.202 (0.766–1.884) | 1.203 (0.743–1.947) |
TT | 5 (2.3) | 3 (0.9) | 0.430 (0.102–1.824) | 0.551 (0.117–2.610) |
CT + TT | 42 (18.9) | 65 (20.6) | 1.110 (0.720–1.711) | 1.132 (0.710–1.803) |
rs3801004 | ||||
CC | 208 (93.7) | 295 (93.4) | 1.00 (reference) | 1.00 (reference) |
CG | 14 (6.3) | 20 (6.3) | 1.007 (0.497–2.040) | 1.321 (0.619–2.820) |
GG | 0 (0.0) | 1 (0.3) | — | — |
CG + GG | 14 (6.3) | 21 (6.6) | 1.058 (0.526–2.128) | 1.362 (0.642–2.888) |
rs2966447 | ||||
AA | 170 (76.6) | 235 (74.4) | 1.00 (reference) | 1.00 (reference) |
AT | 48 (21.6) | 74 (23.4) | 1.115 (0.738–1.686) | 1.039 (0.665–1.621) |
TT | 4 (1.8) | 7 (2.2) | 1.266 (0.365–4.393) | 0.962 (0.252–3.676) |
AT + TT | 52 (23.4) | 81 (25.6) | 1.127 (0.755–1.682) | 1.033 (0.670–1.592) |
rs852479 | ||||
AA | 161 (72.5) | 210 (66.5) | 1.00 (reference) | 1.00 (reference) |
AC | 57 (25.7) | 94 (29.7) | 1.264 (0.858–1.863) | 1.187 (0.783–1.799) |
CC | 4 (1.8) | 12 (3.8) | 2.300 (0.728–7.264) | 1.608 (0.476–5.436) |
AC + CC | 61 (27.5) | 106 (33.5) | 1.332 (0.915–1.940) | 1.219 (0.813–1.827) |
rs1640233 | ||||
CC | 171 (77.0) | 233 (73.7) | 1.00 (reference) | 1.00 (reference) |
CT | 43 (19.4) | 75 (23.7) | 1.280 (0.838–1.955) | 1.386 (0.877–2.190) |
TT | 8 (3.6) | 8 (2.6) | 0.734 (0.270–1.994) | 0.740 (0.251–2.186) |
CT + TT | 51 (23.0) | 83 (26.3) | 1.194 (0.800–1.783) | 1.284 (0.832–1.980) |
