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Figure 1

From: β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle

Figure 1

Experimental Preparations. Section of the left ventricular marginal area from a donor human hearts was dissected into a coronary perfused wedge preparation. (a) Orientation of the preparation was labeled accordingly. Color squares indicate recordings sites of the representative optical traces, illustrating that the tissue was fully perfused on the transmural surface. (b) Representative traces of how different repolarization % changes APD and ∆APD between conditions were calculated. (c) A third order sigmoidal curve was fitted to ∆APD80 vs Log (nM) for the dose response of JNJ-303. Log(IC50) was obtained as 1.82 ± 0.13 (±S.E.). 95% confidence interval for IC50 in nM was between 35.4 and 128.4 nM. Best fit value was determined to be 66.7 nM.

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