Table 1 Regions of Dissociated Vasomotor and Metabolic Levodopa Responses.

From: Levodopa-induced abnormal involuntary movements correlate with altered permeability of the blood-brain-barrier in the basal ganglia

Voxel Search

Coordinates

Cluster Size (Voxels)

Zmax

p-valuea

CBF

CMR

Interaction Effect (VOI Analysis)

x

y

z

OFF/PRE

ON

OFF/PRE

ON

F-valuec

p-value

CBF/CMR × OFF/ON

3.2

−1.4

−7.2

49

3.78

p < 0.001

1.04(0.20)b

1.34(0.18)

1.13(0.07)b

1.16(0.07)

10.85

0.011

CBF/CMR × PRE/ON

3.4

−1.4

−7.4

107

4.12

p < 0.001

1.05(0.10)

1.29(0.20)

1.21(0.05)

1.17(0.08)

16.42

0.005

  1. aCorrected for cluster extent at p ≤ 0.05.
  2. bMean(SD) for local cerebral blood flow (CBF) and cerebral metabolic rate for glucose (CMR) in each of the significant clusters.
  3. cF-tests for tracer × condition interaction effects in each volume-of-interest (VOI); repeated measured analysis of variance (RMANOVA).
  4. PRE = drug-naïve baseline condition; OFF = saline injection; ON = levodopa injection following three weeks of daily drug administration (see text).
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