Table 2 Regions of Increased [11C]-AIB Uptake.

From: Levodopa-induced abnormal involuntary movements correlate with altered permeability of the blood-brain-barrier in the basal ganglia

Voxel Search

Coordinates

Cluster Size (Voxels)

Zmax

p-valuea

[11C]-AIB Uptake

Levodopa Effect (VOI Analysis)

x

y

z

OFF/PRE

ON

T-valuec

p-value

ON > OFF

2.8

−0.8

−5.1

159

4.29

p < 0.001

0.60(0.14)b

0.83(0.17)

3.59

0.006

ON > PRE

2.6

−0.7

−4.9

144

4.20

p < 0.001

0.76(0.16)

0.95(0.13)

3.40

0.009

  1. aCorrected for cluster extent at p ≤ 0.05.
  2. bMean(SD) for local [11C]-AIB uptake in each of the significant clusters.
  3. cT-values for changes in each volume-of-interest (VOI); paired Student’s t-tests.
  4. PRE = drug-naïve baseline condition; OFF = saline injection; ON = levodopa injection following three weeks of daily drug administration (see text).
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