Table 4 Univariate Cox proportional hazards analyses for 28-day all-cause mortality per 1 mEq/L increase of chloride concentration in normochloremic group.

From: An increased chloride level in hypochloremia is associated with decreased mortality in patients with severe sepsis or septic shock

Variables (n = 498)

HR (95% CI)

p-value

Delta chloride for 24 hours (ΔCl24h)

0.879 (0.821–0.942)

<0.001

Delta chloride for 48 hours (ΔCl48h)

0.903 (0.842–0.967)

0.004

Delta chloride for 72 hours (ΔCl72h)

0.895 (0.837–0.957)

0.001

  1. Abbreviations; HR, hazard ratio; CI, confidence interval. Definitions; The 24 hour delta chloride concentration (ΔCl24h) (mEq/L) was calculated by the following formula: [Cl24h] − [Clat baseline], where Cl24h is the chloride concentration at 24 hour, and Clat baseline is the baseline chloride concentration. The 48 hour delta chloride concentration (ΔCl48h) (mEq/L) was calculated by the following formula: [Cl48h] − [Clat baseline], where Cl48h is the chloride concentration at 48 hour, and Clat baseline is the baseline chloride concentration. The 72 hour delta chloride concentration (ΔCl72h) (mEq/L) was calculated by the following formula: [Cl72h] − [Clat baseline], where Cl72h is the chloride concentration at 72 hour, and Clat baseline is the baseline chloride concentration.
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