Table 7 Multivariate Cox proportional hazards analyses for 28-day all-cause mortality per increase of chloride concentration for 24, 48 & 72 hours in normochloremic group.

From: An increased chloride level in hypochloremia is associated with decreased mortality in patients with severe sepsis or septic shock

Variables (n = 297)

Multivariate

24 hours

48 hours

72 hours

HR (95% CI)

Variables (n = 297)

HR (95% CI)

Variables (n = 297)

HR (95% CI)

Variables (n = 297)

Delta chloride (per 1 mEq/L increase of chloride level)

0.930 (0.853–1.014)

0.098

0.986 (0.907–1.072)

0.747

0.975 (0.896–1.062)

0.562

Age (per 1year increase)

1.008 (0.979–1.037)

0.604

1.009 (0.977–1.042)

0.576

1.004 (0.972–1.038)

0.792

Male (vs. Female)

1.372 (0.711–2.648)

0.345

1.485 (0.704–3.133)

0.300

1.848 (0.827–4.127)

0.134

SOFA score (per 1unit increase)

1.117 (1.000–1.248)

0.050

1.134 (1.005–1.279)

0.042

1.124 (0.992–1.274)

0.066

BUN (per 1 mg/dL increase)

1.013 (1.003–1.023)

0.008

1.013 (1.001–1.024)

0.028

1.014 (1.002–1.026)

0.027

Albumin (per 1 g/dL increase)

0.527 (0.328–0.845)

0.008

0.334 (0.201–0.556)

<0.001

0.339 (0.200–0.573)

<0.001

Total CO2 (per 1mEq/L increase)

0.996 (0.918–1.080)

0.915

1.024 (0.933–1.123)

0.620

1.027 (0.934–1.130)

0.579

  1. Abbreviations; HR, hazard ratio; CI, confidence interval; SOFA, sequential organ failure assessment; BUN, blood urea nitrogen.
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