Figure 1 | Scientific Reports

Figure 1

From: Recurring Amplification at 11q22.1-q22.2 Locus Plays an Important Role in Lymph Node Metastasis and Radioresistance in OSCC

Figure 1

Copy number amplification of 11q13.3 and 11q22.1-q22.2 in OSCC. (A) nuc ish on metaphase chromosome confirmed the specificity of clones for 11CEP (red) and 11q locus (green) for (a) 11q13.3 (b) 11q22.1-q22.2. nuc ish signals were categorized as (c) normal (diploid nuclei), (d) weak amplification and (e) strong amplification, nuclei counterstained with DAPI (blue), original magnification 630X. Respective single nuclei zoom for each category are depicted in cz, dz and ez. (B) Kaplan-Meier plot representing disease specific survival (DSS) of patient groups without 11q22.1-q22.2 alteration and with 11q22.1-q22.2 strong amplification (p = 0.003). (C) Kaplan-Meier plot representing recurrence-free survival (RFS) of patient groups without 11q22.1-q22.2 alteration and with 11q22.1-q22.2 strong amplification (p = 0.038).

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