Table 6 Results of external validation experiments providing a comparison of the efficiency of the various evaluated diversity and inequality metrics in predicting a preterm delivery outcome.

From: First-trimester vaginal microbiome diversity: A potential indicator of preterm delivery risk

 

TCS

Shannon

Simpson

Chao1

Gini

Ricci-Schutz

Atkinson

Theil

Decile ratio (90:10)

Accuracy

0.924

0.784

0.880

0.897

0.947

0.940

0.937

0.940

0.924

Sensitivity

0.667

0.500

0.111

0.778

0.556

0.556

0.611

0.611

0.167

Specificity

0.940

0.802

0.929

0.905

0.972

0.965

0.958

0.961

0.972

PPV

0.414

0.138

0.091

0.341

0.556

0.500

0.478

0.500

0.273

NPV

0.978

0.962

0.943

0.985

0.972

0.972

0.975

0.975

0.948

MCC

0.487

0.174

0.037

0.472

0.527

0.495

0.508

0.521

0.175

  1. These experiments were performed using vaginal microbiome samples obtained before 20 weeks of gestation (from studies 2, 3, and 4).