Figure 1 | Scientific Reports

Figure 1

From: Non-Invasive whole-body detection of complement activation using radionuclide imaging in a mouse model of myocardial ischaemia-reperfusion injury

Figure 1

C3d is detected by 99mTc-rCR2 imaging using NanoSPECT-CT. Following the IRI or sham procedures, mice received an intravenous injection of 99mTc-rCR2, 99mTc-PSMA or 99mTc-K41E CR2. After 1hr, the mice underwent imaging for 45 min using NanoSPECT-CT. Signals were present in the liver [Li], Kidneys [K] and bladder [B]. The white arrow indicates the location of the heart. (A) Whole body SPECT-CT imaging of BL/6 or C3−/− mice injected with 99mTc-rCR2, 99mTc-PSMA or 99mTc-K41E CR2. (B) SPECT-CT, Sagittal, Coronal and Transverse images of the region of the infarcted hearts, H = Head, F = Feet, L = Left, R = Right, P = Posterior and A = Anterior. Focal uptake shown in red box.

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