Figure 3 | Scientific Reports

Figure 3

From: Histopathological, immunohistochemical, and ultrastructural evidence of spontaneous Senecavirus A-induced lesions at the choroid plexus of newborn piglets

Figure 3

Histopathological findings observed in newborn piglets naturally infected by SVA. Ureter, there is severe hyperplasia and balloon degeneration of the urothelium (A). Urinary bladder, observe ballooning degeneration of the transitional epithelium associated with an intracytoplasmic, eosinophilic inclusion body (arrow) (B). There is severe focally extensive nonsuppurative meningoencephalitis (*, C) and cerebrocortical necrosis of the brain (D); observe several ischemic neurons (arrows). There is severe multifocal nonsuppurative choroid plexitis (*) of the lateral ventricle (E); observe the intraluminal accumulation of fibrin (★) in a fenestrated capillary, degeneration of ependymocytes and (open arrows), ballooning degeneration (arrow head) as compared with normal (closed arrow) ependymocytes (F). There is malacia (★) of the brainstem with gliosis (G), and discrete perivascular cuffing formed by lymphocytes and macrophages at the cortex (H). Haematoxylin & Eosin stain. Bar, A, E 50 µm; B 5 µm; C 100 µm; D,F–H 20 µm.

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