Table 2 Comparison of validated variants between remaining patients from two leprosy families and healthy controls from 1000 project database.
From: Identification of novel genetic loci GAL3ST4 and CHGB involved in susceptibility to leprosy
Gene | SNP | Minor/Major Allele | Minor Allele Frequency from 1000 project | Patient (N = 6) Minor Allele Frequency | x 2 | P value |
|---|---|---|---|---|---|---|
CHGB23 | rs910122 | A/G | 0.45 | 0.75 | 4.242 | 0.039 |
CHGB48 | rs236152 | C/G | 0.45 | 0.25 | 1.881 | 0.170 |
GAL3ST4 | rs3823646 | G/A | 0.39 | 0.34 | 4.732 | 0.03 |
GLT8D2 | rs17035120 | T/C | 0.34 | 0.5 | 0.723 | 0.395 |
ANKRD35 | rs11579366 | C/G | 0.25 | 0.5 | 2.621 | 0.105 |
GIN1 | rs34813 | A/G | 0.42 | 0.42 | 0 | 1 |
KRT83 | rs11579366 | C/G | 0.25 | 0.17 | 0.102 | 0.749 |
NOM118 | rs2302445 | A/G | 0.26 | 0.25 | 0 | 1 |
C18orf56 | rs2853533 | C/G | 0.55 | 0.83 | 3.784 | 0.052 |
VWA3A | rs1105929 | C/T | 0.30 | 0.25 | 0.003 | 0.95 |
HERC6 | rs17014118 | T/C | 0.28 | 0.5 | 1.762 | 0.184 |
TEKT3 | rs230898 | G/C | 0.49 | 0.25 | 2.699 | 0.1 |
NOM124 | rs2302443 | C/G | 0.26 | 0.25 | 0 | 1 |
NOM148 | rs12919 | A/G | 0.26 | 0.25 | 0 | 1 |
DCHS1 | — | −/CAG | — | 0.5 | — | — |
