Figure 5 | Scientific Reports

Figure 5

From: Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet

Figure 5

Deterioration of beta cell mass and function in autophagy-deficient mice after high-fat and high-glucose feeding. Beta cell mass (A), beta cell proliferation (B), and random blood glucose (C) were measured in each group. Serum insulin levels (D) were measured using ELISA. Intraperitoneal glucose tolerance test (E) and insulin tolerance test (F) were performed after 12 weeks of feeding. Blood glucose levels were examined at 0, 15, 30, 60, 90, and 120 min after dosing. Data were expressed as mean ± SD from three to six independent experiments. *p < 0.05, HFHG + AAV-GFP and HFHG + AAV-shAtg7 versus STD + AAV-GFP or STD + AAV-shAtg7. #p < 0.05, HFHG + AAV-GFP versus HFHG + AAV-shAtg7. Abbreviations: STD, standard diet; HFHG, high-fat diet and high-glucose water; ELISA, enzyme-linked immunosorbent assay.

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