Table 1 Overview of 70 significant DEGs comparing rapid and slow groups (q-value < 0.05).

From: RNA-seq of serial kidney biopsies obtained during progression of chronic kidney disease from dogs with X-linked hereditary nephropathy

Up-regulated DEGs in the rapid group

Gene Symbol

Full Name

Fold Change

q-value

COL1A1

collagen type I alpha 1 chain

6.52

2.62E-20

COL3A1

collagen type III alpha 1 chain

5.35

1.05E-17

COL1A2

collagen type I alpha 2 chain

4.01

4.66E-13

COL5A1

collagen type V alpha 1 chain

3.8

7.21E-05

COL6A3

collagen type VI alpha 3 chain

3.27

7.08E-07

COL6A1

collagen type VI alpha 1 chain

3.26

1.82E-05

LOX

lysyl oxidase

3.13

1.42E-03

COL6A2

collagen type VI alpha 2 chain

3.07

2.34E-04

PAMR1

peptidase domain containing associated with muscle regeneration 1

2.99

5.76E-03

CDCA8

cell division cycle associated 8

2.98

2.80E-02

COL11A1

collagen type I alpha 1 chain

2.86

5.33E-03

COL15A1

collagen type XI alpha 1 chain

2.82

6.24E-03

C1QTNF6

C1q and tumor necrosis factor related protein 6

2.81

4.98E-03

FNDC1

fibronectin type III domain containing 1

2.81

3.22E-02

FN1

fibronectin 1

2.8

4.10E-02

CCDC80

coiled-coil domain containing 80

2.72

7.98E-04

MFSD7

major facilitator superfamily domain containing 7

2.7

3.22E-02

FBLN1

fibulin 1

2.69

4.10E-02

NID2

nidogen 2

2.61

1.52E-07

COL4A2

collagen type IV alpha 2 chain

2.6

1.42E-03

FAM69B

family with sequence similarity 69, member B

2.6

3.42E-02

NDN

necdin

2.59

4.39E-02

COL4A1

collagen type I alpha 1 chain

2.59

5.76E-03

HTR7

5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled

2.58

2.60E-02

PCOLCE

procollagen C-endopeptidase enhancer

2.58

5.83E-03

OLFML2B

olfactomedin like 2B

2.56

6.24E-03

TK1a

Thymidine kinase 1

2.49

1.98E-02

C15orf39

chromosome 15 open reading frame 39

2.47

2.76E-02

RCN3

reticulocalbin 3

2.46

6.94E-04

MFAP2

microfibrillar associated protein 2

2.45

1.42E-03

HSPG2

perlecan

2.45

1.20E-02

PRSS35

protease, serine 35

2.45

4.10E-02

MMP2

matrix metallopeptidase 2

2.43

4.48E-05

FBN1

fibrillin 1

2.37

3.57E-03

CD248

CD248 molecule

2.36

2.72E-02

FOXRED2

FAD dependent oxidoreductase domain containing 2

2.35

1.11E-02

GXYLT2

glucoside xylosyltransferase 2

2.34

3.62E-02

FSCN1

fascin actin-bundling protein 1

2.34

1.20E-02

ENSCAFG00000008741b

novel gene

2.29

1.18E-02

ENSCAFG00000012963b

novel gene

2.28

1.23E-03

BGN

biglycan

2.19

1.85E-02

FAS

Fas (TNF receptor superfamily member 6)

2.16

2.08E-02

ADAMTS2

ADAM metallopeptidase with thrombospondin type 1 motif 2

2.15

3.23E-02

PXDN

peroxidasin

2.14

4.10E-02

SPARC

secreted protein acidic and cysteine rich

2.13

4.48E-05

THBS1

thrombospondin 1

2.12

1.26E-04

KCP

kielin/chordin-like protein

2.12

4.19E-02

LRP1

LDL receptor related protein 1

2.11

7.98E-04

CERCAM

cerebral endothelial cell adhesion molecule

2.11

4.39E-02

ITGA5

integrin subunit alpha 5

2.07

7.03E-03

BMP1

bone Morphogenetic Protein 1

1.88

6.74E-05

FSTL1

follistatin Like 1

1.72

1.25E-05

PTGFRN

prostaglandin F2 Receptor Inhibitor

1.66

2.61E-05

Down-regulated DEGs in the rapid group

UGT1A6

UDP glucuronosyltransferase family 1 member A6

−4.77

1.23E-03

NAT8

N-acetyltransferase 8 (putative)

−4.1

1.09E-04

R3HDML

R3H domain containing like

−4.02

1.42E-03

LIX1

limb and CNS expressed 1

−3.83

7.21E-03

PRLR

prolactin receptor

−3.73

4.64E-04

SCD5c

stearoyl-CoA desaturase 5

−3.55

1.07E-05

FMO2

flavin containing monooxygenase 2

−3.42

1.78E-02

OAT3/SLC22A8

solute carrier family 22 member 8

−3.37

2.45E-02

SI

sucrase-isomaltase

−3.25

1.16E-02

ENSCAFG00000003760b

novel gene

−2.92

3.96E-02

SLC26A4

solute carrier family 26 member 4

−2.79

7.14E-03

ENSCAFG00000000799b

novel gene

−2.77

3.25E-02

HEPACAM2

HEPACAM family member 2

−2.66

8.81E-03

IDO2

indoleamine 2,3-dioxygenase 2

−2.58

3.42E-02

PECR

peroxisomal trans-2-enoyl-CoA reductase

−2.57

6.24E-03

MT-ND3

mitochondrially encoded NADH dehydrogenase 3

−2.16

3.49E-03

ABCA4

retinal-specific ATP-binding cassette transporter

−1.91

1.08E-04

  1. aDEG identified only at T1. bGenes are displyed with ensembl IDs if gene annotations are unavailable. cDEG identified at both T1 and T2.