Figure 2
From: Structural insights into the potency of SK channel positive modulators
Shared binding site of the SK channel positive modulators. (a) Electron density map (grey, |F o|-|F c|) showing the presence of additional electron density at the interface between CaM (cyan) and the CaMBD (salmon). The map is contoured at 3.7 σ and is overlaid with the current refined coordinates for SKS-11. (b) Electron density map (grey) showing the presence of additional electron density. The map is contoured at 3.7 σ and is overlaid with the current refined coordinates for SKS-14. (c) NS309, SKS-11, SKS-14 and 1-EBIO all bind to the interface between the CaM (cyan) N-lobe and the CaMBD (salmon). (d) Overlaid conformations of compounds obtained from their respective protein complex crystal structures. The carbon atoms of the compounds are shown in pale green (NS309), grey (SKS-11), magenta (SKS-14) and yellow (1-EBIO).
