Figure 2 | Scientific Reports

Figure 2

From: Profiling of the transcriptional response to all-trans retinoic acid in breast cancer cells reveals RARE-independent mechanisms of gene expression

Figure 2

DAC treatment does not align atRA-induced transcriptional profiles. Hierarchical clustering (heatmap.2, gplots) of microarray expression values from MDA-MB-231 and MDA-MB-468 cells treated with atRA, DAC, or both demonstrate that the use of DAC did not align the RA-inducible transcriptional profiles in these cell lines. Genes which were commonly upregulated in both cell lines are indicated by * on the right-hand side, while limited clusters of genes which displayed DAC-permissive atRA inducibility are indicated by lowercase Roman numerals. These genes are described in more detail in Supplementary Table S3.

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