Figure 3 | Scientific Reports

Figure 3

From: Profiling of the transcriptional response to all-trans retinoic acid in breast cancer cells reveals RARE-independent mechanisms of gene expression

Figure 3

Decitabine does not restore atRA inducibility of specific genes between cell lines. (a) MDA-MB-231 and MDA-MB-468 cells were treated with atRA, DAC, and/or TSA and relative expression of GDF15, CDH5, and SCEL were determined by qPCR. A two-way analysis of variance was used to compare the effect of atRA treatment to the effects of DAC and/or TSA treatment (n = 4, *p < 0.05, **p < 0.01, ***p < 0.001). (b) β-values representing the relative methylation (Illumina HM450 arrays) of distinct CpG sites in MDA-MB-231 and MDA-MB-468 cells treated with DAC are compared within 1500 bp of the transcription start site (TSS) (n = 3, GSE103425).

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