Figure 4
From: IL-27, but not IL-35, inhibits neuroinflammation through modulating GM-CSF expression
IL-27HA and IL35HA modulate the number of microglia and CNS infiltrating lymphocytes and macrophages. FACS analysis of CNS-infiltrating cells from Lenti-GFP (A), IL-27HA (B) and IL-35HA (C) treated EAE mice, for total CD45+CD11b− lymphoid cells, CD45hiCD11b+ infiltrating macrophages, and CD45lowCD11b+ resident microglia. Lenti-IL-27HA exhibited ability to reduce the number of CNS-infiltrating lymphocytes (D) and infiltrating macrophages (E). *p < 0.05; (1 way anova; (D–F) n = 6/group).
