Figure 1

Impact of deletion of Slco2a1 on survival and growth of intestinal polyps in Apc ^Δ716/+ mice. (a) Survival curves of Slco2a1 ^+/+/Apc ^∆716/+ (broken line, n = 38 including 23 males and 15 females), Slco2a1 ^+/−/Apc ^Δ716/+ (grey line, n = 35 including 17 males and 18 females), and Slco2a1 ^−/−/Apc ^Δ716/+ (solid line, n = 9 including 6 males and 3 females). Diamond shows censored data. Cumulative survival rate was analysed by Kaplan-Meier method for each cohort. (b,d) Number of overall total polyps in the small and large intestine in Slco2a1 ^+/+/Apc ^∆716/+ (+/+, white), Slco2a1 ^+/−/Apc ^Δ716/+ (+/−, grey), and Slco2a1 ^−/−/Apc ^Δ716/+ (−/−, black). Number accounts for all polyps under the stereomicroscope. (c,e) Number of polyps are shown for three different size based on diameter in the small and large intestines. Each mouse was sacrificed at age of 13 weeks. Each bar represents the mean ± SEM. (n = 5–8). *, **, and *** indicate significant difference in polyp number of polyps by Student’s t-test with p < 0.05, <0.01, and <0.001, respectively.