Figure 6 | Scientific Reports

Figure 6

From: CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway

Figure 6The alternative text for this image may have been generated using AI.

Fecal metabolomic analysis revealed the relevance of HMG-CoA reductase pathway. (A) Fecal samples were collected at the end of the experiments. Fecal metabolomic analysis showed the metabolites changed by TNBS and oral CSA13-Eudragit exposure. Only statistically-changed metabolites were shown here. (B) Colonic HMG-CoA reductase mRNA expression. (C) Colonic HMG-CoA reductase activity. 6 mice per group. (D) HMG-CoA reductase activity in human colonic fibroblasts after incubation with CSA13 for 24 hours. (E) Collagen mRNA expression in human colonic fibroblasts after incubation with mevalonate for 24 hours. (F) The CCD18Co fibroblasts were incubated with mevalonate for 24 hours. The cell viability was determined by MTS assay at 490 nm. The results are representative of three experiments.

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