Figure 6 | Scientific Reports

Figure 6

From: Deficiency of a brain-specific chemokine-like molecule, SAM3, induces cardinal phenotypes of autism spectrum disorders in mice

Figure 6

Increased repetitive behaviors were identified for Sam3 −/− and Sam3 +/− male mice and Sam3 −/− female mice. (A) Number of marbles buried during the marble burying test by male mice. Sam3 +/+, n = 15; Sam3 +/−, n = 19; Sam3 −/−, n = 13; one-way ANOVA with Bonferroni’s post hoc test, F(2,44) = 4.621, *p = 0.0151. (B) Number of marbles buried during the marble burying test by female mice. Sam3 +/+, n = 19; Sam3 +/−, n = 17; Sam3 −/−, n = 13; one-way ANOVA with Bonferroni’s post hoc test, F(2,49) = 0.5950, p = 0.5555. (C) Cumulative time spent self-grooming in male mice. Sam3 +/+, n = 12; Sam3 +/−, n = 11; Sam3 −/−, n = 10; one-way ANOVA with Bonferroni’s post hoc test, F(2,30) = 3.846, *p = 0.0526. (D) Cumulative time spent self-grooming in female mice. Sam3 +/+, n = 10; Sam3 +/−, n = 10; Sam3 −/−, n = 11; one-way ANOVA with Bonferroni’s post hoc test, F(2,28) = 4.318, p = 0.0232. Data are expressed as the mean ± SEM (*p < 0.05, **p < 0.01). Data are expressed as the mean ± SEM.

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