Figure 5 | Scientific Reports

Figure 5

From: Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism

Figure 5

Food exploring and hot plate tests. (a) Food exploring test at 7-weeks [(1), male WT, n = 15; male Crmp4-KO, n = 15; female WT, n = 12; and female Crmp4-KO, n = 16] and 11-weeks [(2), male WT, n = 11; male Crmp4-KO, n = 15; female WT, n = 10; and female Crmp4-KO, n = 15] to measure time needed to find buried food. (b) Hot plate test to assess acute pain sensitivity to a thermal stimulus. The time needed to respond with a hind paw lick, paw shake or jump was measured. Male WT, n = 21; male Crmp4-KO, n = 16; female WT, n = 26; and female Crmp4-KO, n = 24. Values are expressed as mean ± SEM.

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