Figure 6 | Scientific Reports

Figure 6

From: Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism

Figure 6

Ultrasonic vocalisations (UVs) emitted by mouse pups under different sensory stimuli. (a) Mean numbers of UVs emitted from wild-type [WT (male, n = 11: female, n = 12)] and Crmp4-knockout pups (male, n = 14: female, n = 16) were compared under exposure to familiar and unfamiliar nest bedding (b) and under exposure at 23 °C [room temperature, RT (male WT, n = 8; male Crmp4-KO, n = 8; female WT, n = 13; and female Crmp4-KO, n = 6)], 19 °C (male WT, n = 11; male Crmp4-KO, n = 15; female WT, n = 14; and female Crmp4-KO, n = 16), and 9 °C (male WT, n = 13; male Crmp4-KO, n = 14; female WT, n = 12; and female Crmp4-KO, n = 10). Values are expressed as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 (three-way ANOVA followed by Fisher’s PLSD post-hoc tests).

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