Figure 4
From: HIDEEP: a systems approach to predict hormone impacts on drug efficacy based on effect paths
Underlying mechanism analysis of previous works through HIDEEP. Each node type means drug (black), hormone (purple), drug target (green), disease gene (red), hormone target (yellow), intermediate molecule (gray). HIDEEP analyze crosstalk mechanisms of known hormone-drug pairs discovered by previous studies. (a) Epinephrine-BADS112A (prostate cancer). (b) Epinephrine-LY294002 (prostate cancer). (c) Dexamethasone-paclitaxel (breast cancer). (d) Dexamethasone-doxorubicin (breast cancer).
