Figure 6
From: HIDEEP: a systems approach to predict hormone impacts on drug efficacy based on effect paths
Drug effect paths and hormone effect paths. Each node type means drugs (drug symbol), hormones (purple), drug targets (green), disease genes (red), hormone targets (yellow), and other molecules (gray). (a) Drugs can therapeutically target disease genes in direct or indirect ways. (b) A drug targets subset of diseases genes clustering each other, forming a disease module (light red area). (c) Drug effect paths are defined as the shortest paths from each drug target to the nearest disease gene. (d) Hormone effect paths are defined as the very shortest paths among the shortest paths from each receptor to the nearest molecule of drug effect paths (light purple area).
