Figure 5
From: Immune tuning scaffold for the local induction of a pro-regenerative environment
Inflammatory proteins expression induced by CSCL. (A) Differences in the rat cytokines/chemokines profiling of CSCL at 3 days and 7 days. Proteins adsorbed on CSCL surface were extracted. Proteins with different levels of abundance at 3 and 7 days are represented. Bar graph presents mean densitometry units of each spot. Values are presented as the mean ± SD. (B) Quantitative PCR analysis for the pro-inflammatory (Il-6, Tnf-α Il-1β, iNos)- associated markers at 3 and 7 days from CSCL implants. Expression levels normalized to the reference gene (Gapdh). Data are represented as fold-change compared with expression observed in subcutaneous tissues explanted from rats in absence of inflammation. Values are mean ± SD (n = 3). Asterisks depict significant differences between 3 and 7 days (**p < 0.01).
