Figure 12
From: Deep tissue analysis of distal aqueous drainage structures and contractile features
Filamentous actin distribution in mouse trabecular meshwork. (a–c) Pore-like gaps, similar to those found in human TM, were evident in the mouse TM (a,b, and c inset). At z = 8 μm internal to IWSC, gaps had diameters of 20–40 μm (b), but at z = 16 μm, further internal to IWSC, gap diameters exceeded 40 μm (c), reminiscent of pore size variation with depth in the human trabecular meshwork. (d–f) Further internally, the mouse TM interfaced with ciliary muscle (d,e) in which the pattern of large pore-like gaps was absent. Green: autofluorescence from structural extracellular matrix (a; predominantly sclera). Insets: 2X magnifications of regions indicated by asterisks.
