Table 1 Main characteristics of the eligible studies.

	Study [Year]	Time interval of collected data	Total	Men/ women	UICC stage	Localization	HPV subtypes	Mean age [Year]
1	Wittekindt C²³	—	34	25/9	I-IV	OPSCC	16, 33	61
2	Smith EM²⁴	1994–2004	301	188/113	I-IV	all	16, 33, 18
3	Kong CS²⁵	—	99	69/13	II-IV	all	16, 18, 33
4	Weinberger PM²⁶	1980–1999 (Yale), 2004–2007 (Georgia)	140	106/34	I-IV	all	16, 18	60.3
5	Heath S²⁷	2004–2007	83	48/35	I-IV	all	HPV16	64
6	Park WS²⁸	2002–2007	93	80/13	I-IV	OPSCC	16, 18, 33	62.1
7	Holzinger D²⁹	1990–2008	199	146/50	I-IV	OPSCC	16, 18, 33, 35	57
8	Liang C³⁰	1999–2003	844		I-IV	all	16
9	Park K³¹	2000–2008	142	73/6	III-IV	OPSCC		54
10	Evans M³²	2001–2006	147	104/34	I-IV	all	16, 18, 33, 56	58.1
11	Stephen JK³⁴	1986–2003	80	66/14	I-IV	all	16
12	Rietbergen MM³⁵	2000–2006	841		I-IV	OPSCC	16, 35, 33, 18, 45, 58
13	Huang H, 2013³⁶	1999–2009	66		I-IV	OPSCC	16,33,11,35,52,54,58	59
14	Semrau R⁴¹	2000–2008	52	42/10	III-IV	OPSCC	16, 18, 33, 35	56.3
15	Melkane AE³³	2007–2009	133	94/39	I-IV	OPSCC	16, 18, 33	59
16	Salazar CR³⁷	—	158	110/43	I-IV	OPSCC	16
17	Heiduschka G³⁹	2002–2013	103	46/17	II-IV	OPSCC		60.5
18	Chung CH⁴⁰	—	683		III-IV	all non-OPSCC		58
19	Ramshankar V⁴²	1995–2007	167	108/48	I-II	HNSCC	16
20	Xu Y³⁸	2004–2013	278	229/27	I-IV	all	11, 16, 33
21	Liu JC⁴³	1990–2010	44	30/14	I-IV	OPSCC	16, 35	64
22	Saito Y⁴⁴	2004–2012	167	130/20	I-IV	all		64
23	Descamps G⁴⁵		218	173/45	II-IV	HNSCC
24	Mazul AL⁴⁶	2002–2006	238		I-IV	OPSCC	6,11,16,18, 26,31,33,35,39,58,59,82
25	Gronhoj Larsen C⁴⁷	2000–2014	1542		I-IV	OPSCC

Footnotes: ICC, Yale, Georgia.
Abbreviations: Union for International Cancer Control, UICC; oropharyngeal squamous cell carcinoma, OPSCC; human papillomavirus, HPV.

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