Table 1 Polygenic score of nicotine dependence is associated with COPD case/control status

From: Genetic Pleiotropy between Nicotine Dependence and Respiratory Outcomes

PGS Training Trait

1e-3 p-value threshold in PGS construction

1e-4 p-value threshold in PGS construction

# SNPs

β

p.value

# SNPs

β

p.value

Cigarettes Per Day

891

0.086

0.025495

116

0.190

1.03E-06

Ever Smoked

1110

0.082

0.030847

142

0.044

0.257046

Former Smoker

858

−0.138

2.37E-04

114

−0.069

0.078856

LogOnset

797

0.028

0.43318

76

−0.023

0.430121

  1. Polygenic score (PGS) formulation is established based on TAG GWAS summary data using 1e-3 and 1e-4 p-value threshold on nicotine dependence (ND) traits. The ND PGS was computed on COPDgene dataset (sample size = 4903), and tested for association with COPD case-control status. #SNPs, the number of SNPs used in PGS computation, β, association coefficient (ie, log Odds Ratio).
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