Table 3 Polygenic score of nicotine dependence is associated with COPD case/control status adjusted for smoking duration

From: Genetic Pleiotropy between Nicotine Dependence and Respiratory Outcomes

PGS Training Trait

1e-3 p-value threshold in PGS construction

1e-4 p-value threshold in PGS construction

# SNPs

β

p.value

# SNPs

β

p.value

Cigarettes Per Day

891

0.085

0.0376

116

0.197

1.82E-06

Ever Smoked

1110

0.072

0.070447

142

0.057

0.163214

Former Smoker

858

−0.132

9.46E-04

114

−0.067

0.106736

LogOnset

797

0.022

0.555505

76

−0.019

0.544609

  1. Polygenic score (PGS) formulation is established based on TAG GWAS summary data using 1e-3 and 1e-4 p value threshold on nicotine dependence (ND) traits. The ND PGS was computed on COPDgene dataset (sample size = 4903), and tested for association with COPD case-control status, adjusted for smoking duration. #SNPs, the number of SNPs used in PGS computation, β, association coefficient (ie, log Odds Ratio).
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